? ? Coronin is an actin binding protein which also interacts with microtubules and in some cell types is associated with phagocytosis.Coronin proteins are expressed in a large number of eukaryotic organisms from yeast to man.
? ? Yeast Coronin Crn1 and Drosophila Dpod1 were found crosslink actin and microtubule cytoskeleton. C.elegans POD-1 and Drosophila Coronin homologue regulate actin cytoskeleton and are involved in vesicular trafficking.
? ? Seven different isoforms of Coronin have been reported in mammals. The most well studied isoforms are Coronin 1 (Coronin 1A) and Coronin 1B. Coronin 1 exerted an inhibitory effect on cellular steady-state F-actin formation via an Arp2/3-dependent mechanism. Whereas Coronin 1 was required for chemokine-mediated migration, it was dispensable for T cell antigen receptor functions in T cells. Coronin 1B is required for efficient cell protrusion and migration. Recent study demonstrates that Coronin 1B inhibits the Arp2/3 complex activity by replacing it at the branched actin structure.Mammalian Coronin-7 does not interact with actin nor does it execute any actin mediated processes, but rather participate in Golgi trafficking.
? ? Although Coronin is present almost all eukaryotic organisms and have different functions, but everywhere these proteins have been shown to bind F-actin and localize in the dynamic F-actin rich area of cells. Recent study shows that Coronin prefers ATP/ADP-Pi containing F-actin over ADP containing F-actin, which might explain their unique cellular localization.
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